图书简介

List of contributors; Part I. Basic Methodological Strategies in Metabolomic Research: 1. Exploring the human metabolome by nuclear magnetic resonance spectroscopy and mass spectroscopy; 2. Methodological requirements for lipidomics research; 3. Biological methods for metabolic research; Part II. Metabolomic Mass Spectrometry: Experimental Techniques and Bioinformatics: 4. Considerations in sample preparation, collection, and extraction approaches applied in microbial, plant, and mammalian metabolic profiling; 5. Mass spectrometry-based methodologies for single-cell metabolite detection and identification; 6. Direct metabolomics from tissues and cells: laser ablation electrospray ionization for small molecule and lipid characterization; 7. Bioinformatic approaches to processing and annotation of high-resolution mass spectrometry data; 8. Approaches for natural product detection and structural elucidation using mass spectrometry with high mass accuracy; 9. Metabolomics using ion mobility mass spectrometry; 10. Metabolomics via biomedical mass spectrometry: from sampling to clinical applications; Part III. Metabolomics of Biofluids: Nuclear Magnetic Resonance Spectroscopy and Chemometrics: 11. Analytical techniques in metabolomics integrating nuclear magnetic resonance spectroscopy and chromatography with mass spectrometry; 12. Chemometric methods in nuclear magnetic resonance-based body fluid analysis; 13. Nuclear magnetic resonance of cerebrospinal fluid: the neurometabolome; 14. Nuclear magnetic resonance-based saliva metabolomics; 15. Nuclear magnetic resonance methods for metabolomic investigation of amniotic fluid; 16. Nuclear magnetic resonance analysis and genetic metabolic disease; 17. Lipid profiling in health and disease; Part IV. Metabolomic Nuclear Magnetic Resonance Spectroscopy Techniques for Body Tissue Analysis: 18. Magnetic resonance spectroscopy in investigating the cancer metabolome in preclinical model systems; 19. Phospholipidomics by phosphorous nuclear magnetic resonance spectroscopy of tissue extracts; 20. Carbon-13 nuclear magnetic resonance for analysis of metabolic pathways; 21. Hyperpolarized nuclear magnetic resonance spectroscopy - a new method for metabolomic research; 22. Metabolomic magnetic resonance spectroscopy of human tissues: comparison of in vivo and high-resolution magic angle spinning ex vivo techniques; 23. Reproducible sample preparation and spectrum acquisition techniques for metabolic profiling of human tissues by proton high-resolution magic angle spinning nuclear magnetic resonance; 24. Assignment strategies for nuclear magnetic resonances in metabolomics research; Index.

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