图书简介
Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences covers every aspect of the drug delivery to lungs, the physiology and pharmacology of the lung, modelling for lung delivery, drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications. With the advent of nano sciences and significant development in the nano particulate drug delivery systems there has been a renewed interest in the lung as an absorption surface for various drugs. The emergence of the COVID-19 virus has brought lung and lung delivery systems into focus, this book covers new developments and research used to address the prevention and treatment of respiratory diseases. Written by well-known scientists with years of experience in the field this timely handbook is an excellent reference book for the scientists and industry professionals.Key Features:Focuses particularly on the chemistry, clinical pharmacology, and biological developments in this field of research.Presents comprehensive information on emerging nanotechnology applications in diagnosing and treating pulmonary diseasesExplores drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applicationsExamines specific formulations targeted to pulmonary systems
1. Introduction to Physiology of Lung from Aparoop Das, Manash Pratim Pathak, Drug delivery perspective Pompy Patwary and Sanghita Das 2. Introduction to pharmacology of Lungs from Caline McCarthy and Charles Preuss Drug delivery perspective 3. Mechanism and ways of Pulmonary Ahmed S Fahad, Sai HS Boddu and drug administration jerry Nesamony 4. Trans-epithelial transport of drugs in Sakshi Kumar and Swati Gupta Pulmonary system 5. Understanding Pharmacokinetics and Seth Kwabena Amponsah pharmacodynamics of lung and lung drug delivery 6. Chronic Lung diseases : Treatment Aproop Das, Riya Saikia, Kalyani Challenges and solutions Pathak, Urvashee Gogoi, and Surovi Saikia 7. Understanding of Lung diseases with a focus on Sharaddha Khairnar, Mudassir applications of nano particulate drug delivery Ansari, Ujwala Shinde, Agnivesh Systems Shrivastava, and Kavita Singh 8. Models for Lung absorption of Puchanee Larpruenrudee, drug delivery systems Mohammad S Islam, Gunther Paul, Akshoy R Paul, Y T Gu and Suyash C Saha 9. Modelling for Dry power inhalers Anurag Tiwari, Akshoy R Paul, Anuj Jain and Suvash C Saha 10. In Vivo Animal models for lung targeted Khushali Vashi, Jasmin Patel and drug delivery systems Yashwant Pathak 11. In Silico Methods for Development of Generic Hao Miao, Reniie LI, Xudong Zhou, Drug-Device Combination Jiaqi Yu, Fen Huang, Haoqin Yang Orally Inhaled Drug Products. and Zhenbo Tong 12. Effect of Aerosol Devices and Administration Amelia Alberts and Charles preuss Techniques on Drug Delivery in a Simulated Spontaneously Breathing Pediatric Tracheostomy Model 13. Pulmonary drug delivery: role for Ofosua Adi-Dako, Doris Kumadoh,, polymeric nanoparticles Esther Eshun Oppong, Christina OseiAsare and Mary Ann Archer 14. Polymeric nanoparticle based drug-gene Keshav Moharir, Vinita Kale and delivery for lung cancer Abhay Ittadwar 15. Inhalable Polymeric nano particulate Jayvadan Patel and Anita Patel powders for respiratory delivery 16. Recent trends in Applications of Doris Kumadoh, Ofosua Adi-Dako Nano-Drug Delivery Systems Yaa Asantewaa Osei and Mary Ann Archer 17. Nanocarrier systems for Pulmonary Sai HS Boddu and jerry Nesamony Drug Delivery 18. Nano medicine for the Management of Pompy Patowary, Manash Pratim Pulmonary Disorders Pathak, Pronobesh Chattopadhyay And Kamaruz Zaman 19. Recent approaches in Dendrimers based Rajiv Dahiya and Sunita Dahiya pulmonary delivery 20. Hybrid Lipid/Polymer Nanoparticles for Pulmonary Samyak nag, Shivani Baliyan and Delivery of siRNA: Development and Swati Gupta Fate Upon In Vitro Deposition on the Human Epithelial Airway Barrier 21. Solid Lipid Nanoparticle-Based Drug Deepa U warrier, harota R Desai, Delivery for Lung Cancer Kavita H Singh and Ujwala A Shinde 22. Lipid-based pulmonary delivery system: a review Komal Parmar and Jayvadan Patel and future considerations of formulation 23. Respirable controlled release polymeric Nazrul Islam and Abdur Rashid colloid (RCRPC) 24. Lung clearance kinetics of solid lipid Soumalya Chakraborty, Sudipta Roy Nano particles and liposomes Akash Dey, Sanjoy Kumar Das, Dhananjoy Saha, Subhabrata Ray, and Bhaskar Mazumder 25. Solid lipid nanoparticles for sustained pulmonary Nayanmoni Boruah, Himangshu delivery of Herbal drugs for Lung delivery: Sharma and Hemanta Kumar Sharma Preparation, characterization and in vivo evaluation 26. Improved Solid Lipid Nano formulations Samson A. Adeyemi, Pradeep For pulmonary delivery of Paclitaxel- Kumar, Viness Pillay and Yahya E Lung cancer Therapy Choonara 27. Antiangiogenic therapy for lung cancer: Urvashi Bhati, Colin J. Barrow Focus on Bioassay development in a Jagat R. Kanwar, Arnab Kapat quest for anti-VEGF drugs Venkata Ramana1 and Rupinder K. Kanwar3* 28. Emerging applications of nanoparticles for Raja Reddy Boma Reddy, Sheshanka lung cancer diagnosis and therapy Kesani and Yashwant V Pathak 29. Metallic nanoparticles: technology overview Komal Parmar and Jayvadan Patel and drug delivery applications in Lung cancer 30. Modelling of pharmaceutical aerosol Anusmriti Ghosh, Mohammad S. transport in the targeted region of human Islam, Mohammad Rahimi-Gorji, lung airways due to external magnetic field Raj Das and Suvash C. Saha 31. Phytochemicals and biogenic metallic Nana Ama Mireku-Gyimah, Rex Particles as anticancer agents in Frimpong Anane and Louis Hamenu Lung cancer 32. Pulmonary applications and toxicity Deepti Kaushlkumar Jani of engineered metallic nanoparticles 33. Anticancer activity of eco-friendly gold nano Jayvadan Patel and Anita Patel particles against lung and liver cancer cells 34. Subchronic inhalation toxicity of gold Srijan Mishra and Jigna Shah nanoparticles 35. Single-use disposable dry powder inhalers for Somchai Sawatdee and Teerapol pulmonary drug delivery Srichana 36. Lung delivery of nicotine for smoking cessation Hui Wang and Nazrul Islam 37. Formulation and characterization of Himangshu Sarma, Nayanmoni Dry powder inhalers for pulmonary drug delivery Boruah, Hemanta K Sharma 38. Devices for dry powder drug delivery to the lung Jayvadan Patel and Anita Patel 39. Numerical Modelling of Agglomeration and Tan Suwandecha and Teerapol Srichana Deagglomeration in Dry Powder Inhalers Srichana 40. Oronasal and Tracheostomy Delivery Dasharath M. Patel, Unnati D of Soft Mist and Pressurized Metered-Dose Chanpura and Veer J. Patel Inhalers With Valved Holding Chamber. 41. Modelling for Biopharmaceutical Amy Le, Kianna Samuel, Truong Performance in Lung Drug Discovery Tran and Yashwant Pathak 42. Regulatory Considerations for Approval of Urvashi K Parmar and Jayvadan Patel Generic Inhalation Drug Products in the US, EU, Brazil, China, and India 43. Regulatory perspectives and concerns Johirul Islam, Hemanga Hazarika related to nano particles based lung delivery Probin Kr Roy, Pompy Patowary Pronobesh Chattopadhyay, Yashwant V Pathak, Kamaruz Zaman 44. Clinical Controversies in Aerosol Jeffrey Cruz and Charles Preuss Therapy for Infants and Children 45. Drug Delivery Using Aerosols: Challenges Surovi Saikia, Aproop Das and and Advances in Neonatal Pediatric Subgroup Yashwant V Pathak 46. Safety and Toxicological Concerns Humera Memon, Vandit Shah Related to Nano-Particles Based Lung Delivery Tejal mehta and Jigna Shah 47. Nanoparticles Based Lung Drug Delivery: Vandit Shah, Jigna Shah
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